Prothrombin Complex Concentrates (PCC) are human plasma derived products that have undergone solvent/detergent treatment and/or nanofiltration for viral, bacterial and parasite inactivation and removal.  They contain procoagulant Vitamin K dependent factors – II, VII, Ix and X.  They also contain the anticoagulant factors Protein C, Protein S and Heparin in varying amounts.  There are two licensed PCCs in Canada: Octoplex and Beriplex P/N.  Beriplex P/N also contains Antithrombin.

Request for Prothrombin Complex Concentrates Form here


Quick Reference for Physicians (6 minute Youtube video)

Quick Reference for Healthcare Providers (6 minute Youtube video)

Octaplex Reconstitution instructions



National Advisory Committee on Blood and Blood Products PCC Recommendations